Neonatal alloimmune thrombocytopaenia associated with maternal HLA antibodies

Foetal and neonatal alloimmune thrombocytopaenia

Foetal/neonatal alloimmune thrombocytopaenia (NAIT) results from maternal alloimmunisation against foetal platelet antigens inherited from the father and different from those present in the mother, and usually presents as a severe isolated thrombocytopaenia in otherwise healthy newborns. The incidence has been estimated at 1/800 to 1/1000 live births. NAIT has been considered to be the platelet...

IVIG-Associated Maternal Pancytopenia during Treatment for Neonatal Alloimmune Thrombocytopenia

Background  Treatment for neonatal alloimmune thrombocytopenia (NAIT) primarily involves maternal administration of intravenous immunoglobulin (IVIG) therapy and prednisone according to protocols based on risk stratification. While IVIG is generally well tolerated, hematologic side effects are a potential complication. Case  We present the successful management of a rare complication of materna...

Specificity and HLA-restriction of CD4 T Cells Associated with Neonatal Alloimmune Thrombocytopenia

Controversy: HLA Antibodies Responsible for Fetal/Neonatal Alloimmune Thrombocytopenia – an Update

This review focuses on reports on fetal/neonatal alloimmune thrombocytopenia (FNAITP) – presumably due to alloimmunization to HLA antigens – published during the last 6 years. Platelets express HLA class I antigens, and HLA antibodies are known to adversely affect the success of platelet transfusions. Likewise, it is conceivable that HLA antigens can serve as targets leading to HLA antibody-ind...

Neonatal alloimmune thrombocytopenia due to HLA-A2 antibody.

A male, full-term baby with thrombocytopenia was born by a G3P2A1 mother who was not associated with autoimmune disease. Platelet antibody screening was positive by using lymphocytotoxicity test, platelet suspension immunofluorescence test and solid-phase red cell adherence test. The identified HLA antibody was of A2 specificity. It was confirmed by testing the mother's and the baby's sera agai...